The Pathogenesis of Rheumatoid Arthritis | NEJM Skip to main content NEJM Group Follow Us
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Osteoimmunology is a new subject which focuses on the communication between the
immune and the skeletal systems. Both the immune system and bone communicate with …

Bone erosion is a central feature of rheumatoid arthritis and is associated with disease
severity and poor functional outcome. Erosion of periarticular cortical bone, the typical …

Osteoporosis has been classically considered a comorbidity of rheumatoid arthritis (RA).
However, recent advances in the pathogenesis of osteoporosis in RA have shown a close …

Bone is a tissue undergoing continuous building and degradation. This remodelling is a
tightly regulated process that can be disturbed by many factors, particularly hormonal …

Tumor necrosis factor-α (TNF-α) plays an essential role in the regulation of bone
homeostasis in several chronic immune and inflammatory joint diseases, where inhibition of …

The adult skeleton regenerates by temporary cellular structures that comprise teams of
juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A …

Objectives We investigated the relationships among M1 monocytes, M2 monocytes,
osteoclast (OC) differentiation ability, and clinical characteristics in patients with rheumatoid …

Degenerative and inflammatory joint diseases lead to a destruction of the joint architecture.
Whereas degenerative osteoarthritis results in the formation of new bone, rheumatoid …

Rheumatoid arthritis is characterised by pain, swelling, and destruction of joints, with
resultant disability. Only disease-modifying antirheumatic drugs can interfere with the …