Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted
rapidly increasing interest as a means to improve discovery of more efficacious and safer …

Increasing attention is being directed towards the role of the serotonergic system in the
neurochemistry of schizophrenia and antipsychotic drug treatment. This review considers …

Background: Ziprasidone (Zeldox) is a novel antipsychotic with a unique combination of
antagonist activities at monoaminergic receptors and transporters and potent agonist activity …

In this review, the functional interactions between serotonin (5-HT) and dopamine (DA)
neuronal systems are discussed with the focus on microdialysis studies in the rodent brain …

In the present study, a novel and exceptionally sensitive method of high-performance liquid
chromatography coupled to coulometric detection, together with concentric dialysis probes …

It has been known for several decades that serotonergic neurotransmission is a key
regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of …

Clozapine (1–10 mg/kg sc) produces a selective increase in dopamine release in rat
prefrontal cortex which is, in large part (~ 50%), mediated via activation of 5-HT1A receptors …

In previous studies, we demonstrated that tandospirone, a serotonin-5-HT1A partial agonist,
added to ongoing treatment with small to moderate doses of typical antipsychotic drugs …