Cellular functions of cGAS-STING signaling
C Chen, P Xu - Trends in cell biology, 2023 - cell.com
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
Structures and mechanisms in the cGAS-STING innate immunity pathway
Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
Structural basis of STING binding with and phosphorylation by TBK1
The invasion of mammalian cytoplasm by microbial DNA from infectious pathogens or by
self DNA from the nucleus or mitochondria represents a danger signal that alerts the host …
self DNA from the nucleus or mitochondria represents a danger signal that alerts the host …
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger
selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates …
selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates …
[HTML][HTML] Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway
C Ding, Z Song, A Shen, T Chen, A Zhang - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Multiple cancer immunotherapies including chimeric antigen receptor T cell and immune
checkpoint inhibitors (ICIs) have been successfully developed to treat various cancers by …
checkpoint inhibitors (ICIs) have been successfully developed to treat various cancers by …
HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity
Sensing cytosolic DNA through the cGAS–STING pathway constitutes a widespread innate
immune mechanism to monitor cellular damage and microbial invasion. Evading this …
immune mechanism to monitor cellular damage and microbial invasion. Evading this …
The IκB kinase complex in NF‐κB regulation and beyond
M Hinz, C Scheidereit - EMBO reports, 2014 - embopress.org
The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed
of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also …
of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also …
The interactions between cGAS-STING pathway and pathogens
Cytosolic DNA is an indicator of pathogen invasion or DNA damage. The cytosolic DNA
sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase …
sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase …
The role of TBK1 in cancer pathogenesis and anticancer immunity
The TANK-binding kinase 1 (TBK1) is a serine/threonine kinase belonging to the non-
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …
Identification and characterization of Von Hippel-Lindau-recruiting proteolysis targeting chimeras (PROTACs) of TANK-binding kinase 1
AP Crew, K Raina, H Dong, Y Qian… - Journal of medicinal …, 2018 - ACS Publications
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3
ligase to a target protein to facilitate ubiquitination and subsequent degradation of that …
ligase to a target protein to facilitate ubiquitination and subsequent degradation of that …