Glucose homeostasis requires an organism to rapidly respond to changes in plasma
glucose concentrations. Iatrogenic hypoglycemia as a result of treatment with insulin or …

Diabetes and obesity are growing problems worldwide and are associated with a range of
acute and chronic complications, including acute myocardial infarction (AMI) and stroke …

Comprehensive transcriptional profiling of glucose-sensing neurons is challenging because
of low expression levels of glucokinase (Gck) and other key proteins that transduce a …

The growing worldwide prevalence of overnutrition and underexertion threatens the gains
that we have made against atherosclerotic cardiovascular disease and other maladies …

This review focuses on evidence indicating a key role for the hindbrain in mobilizing
behavioral, autonomic and endocrine counterregulatory responses to acute and profound …

Orexin-A and-B (identical to hypocretin-1 and-2) are neuropeptides synthesized in the
lateral hypothalamus and perifornical area, and orexin neurons project their axon terminals …

It is increasingly apparent that the brain plays a central role in metabolic homeostasis,
including the maintenance of blood glucose. This is achieved by various efferent pathways …

Glucokinase is a key component of the neuronal glucose-sensing mechanism and is
expressed in brain regions that control a range of homeostatic processes. In this review, we …

Glucose is the essential metabolic fuel for the brain. Acute and severe reduction of brain
glucose leads quickly to impairment of cognitive and reflex function, autonomic failure …

Glucokinase (GK), the hexokinase involved in glucose sensing in pancreatic β cells, is also
expressed in hypothalamic tanycytes, which cover the ventricular walls of the basal …