Acute exposure of cancer cells to high concentrations of type I interferon (IFN-I) drives
growth arrest and apoptosis, whereas chronic exposure to low concentrations provides …

Over the past decade, preclinical and clinical research have confirmed the essential role of
interferons for effective host immunological responses to malignant cells. Type I interferons …

Myeloid-derived suppressor cells (MDSCs) are innate immune cells that acquire the
capacity to suppress adaptive immune responses during cancer. It remains elusive how …

Interferon-induced transmembrane proteins (IFITMs) are broad spectrum antiviral factors that
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …

Inflammatory breast cancer (IBC) is a rare and aggressive disease that accounts for~ 2–4%
of all breast cancers. However, despite its low incidence rate, IBC is responsible for 7–10 …

Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus
kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription …

Breast cancer is the most commonly diagnosed cancer and second-leading cause of cancer
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …

Breast cancer is the most commonly occurring cancer in women. There were over two-
million new cases in world in 2018. It is the second leading cause of death from cancer in …

Hypoxia is a common phenomenon in solid tumors and is strongly linked to hallmarks of
cancer. Recent evidence has shown that hypoxia promotes local immune suppression. Type …

Interferons (IFNs) are important cytokines that regulate immune responses through the
activation of hundreds of genes, including interferon-induced transmembrane proteins …