Early diagnosis and appropriate treatment of primary aldosteronism, the most frequent
cause of secondary hypertension, are crucial to prevent deleterious cardiovascular …

Naringin, chemically 4′, 5, 7-trihydroxyflavanone-7-rhamnoglucoside, is a major flavanone
glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. It has been …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Primary aldosteronism (PA) is the main cause of secondary hypertension, resulting from
adrenal aldosterone-producing adenomas (APA) or bilateral hyperplasia. Here, we show …

Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the
adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium …

Aldosterone is a major mineralocorticoid steroid hormone secreted by glomerulosa cells in
the adrenal cortex. It regulates a variety of physiological responses including those to …

Primary aldosteronism is characterised by the dysregulation of aldosterone production and
comprises both sporadic forms, caused by an aldosterone-producing adenoma or bilateral …

Hypertension is one of the major risk factors of cardiovascular diseases, but despite a
century of clinical and basic research, the discrete etiology of this disease is still not fully …

Aldosterone-producing adenomas (APAs) are one of the main causes of primary
aldosteronism and the most prevalent surgically correctable form of hypertension …

Aldosterone-producing adenomas (APAs) are benign tumors of the adrenal gland that
constitutively produce the salt-retaining steroid hormone aldosterone and cause millions of …