Background Remote monitoring of Huntington disease (HD) signs and symptoms using
digital technologies may enhance early clinical diagnosis and tracking of disease …

Smart mobile phone use is increasing worldwide, as is the ability of mobile devices to
monitor daily routines, behaviors, and even cognitive changes. There is a growing …

Background Speech changes are an early symptom of Huntington disease (HD) and may
occur prior to other motor and cognitive symptoms. Assessment of HD commonly uses …

Developing drugs for rare diseases is challenging, and the precision and objectivity of
outcome measures is critical to this process. In recent years, a number of technologies have …

The Unified Huntington's Disease Rating Scale (UHDRS) is the primary clinical assessment
tool for rating motor function in patients with Huntington's disease (HD). However, the …

Currently doctors rely on tools such as the Unified Parkinson's Disease Rating Scale (MDS-
UDPRS) and the Scale for the Assessment and Rating of Ataxia (SARA) to make diagnoses …

Wearable systems are research-grade or commercial electronic instruments designed to be
worn by the user and to serve a variety of purposes. These devices can detect and collect …

Digital measures can provide quantitative assessment of a range of disease-specific
impairments, including motor, speech, cognition and physiological functioning. People with …

With the emergence of genetic and disease-modifying interventions, there is an urgent need
for early and accurate assessment of disease-specific impairments in Huntington's disease …