In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9 …

Cannabis sativa is best known as the source of marijuana, the world's most widely
consumed illicit recreational drug. However, the plant is also extremely useful as a source of …

Secretion of glucocorticoid hormones during stress produces an array of physiological
changes that are adaptive and beneficial in the short term. In the face of repeated stress …

Marijuana has the highest consumption rate among all of the illicit drugs used in the USA,
and its popularity as both a recreational and medicinal drug is increasing especially among …

Huntington's disease (HD) is a neurodegenerative disease for which there is no curative
treatment available. Given that the endocannabinoid system is involved in the pathogenesis …

Primary astrocytomas of grade 3 or 4 according to the classification system of the World
Health Organization (high-grade astrocytomas or HGAs) are preponderant among adults …

Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors. These
receptors are also the primary molecular target responsible for the pharmacological effects …

Cannabis sativa has long been used for medicinal purposes. To improve safety and efficacy,
compounds from C. sativa were purified or synthesized and named under an umbrella group …

Autophagy is a lysosomal catabolic process essential to cell homeostasis and is related to
the neuroprotection of the central nervous system. Cannabidiol (CBD) is a non-psychotropic …