Understanding how the metazoan genome is used during development and cell
differentiation is one of the major challenges in the postgenomic era. Early studies in …

Development is orchestrated by regulatory elements that turn genes ON or OFF in precise
spatial and temporal patterns. Many safety mechanisms prevent inappropriate action of a …

Genome organization is driven by forces affecting transcriptional state, but the relationship
between transcription and genome architecture remains unclear. Here, we identified the …

Chromatin insulators are DNA-protein complexes that can prevent the spread of repressive
chromatin and block communication between enhancers and promoters to regulate gene …

Drosophila CP190 and CP60 are transcription factors that are associated with centrosomes
during mitosis. CP190 is an essential transcription factor and preferentially binds to …

The molecular biology of metazoan eye development is an area of intense investigation.
These efforts have led to the surprising recognition that although insect and vertebrate eyes …

RNA-binding proteins (RBPs) commonly feature multiple RNA-binding domains (RBDs),
which provide these proteins with a modular architecture. Accumulating evidence supports …

The mechanisms underlying long-range interactions between chromatin regions and the
principles of chromosomal architecture formation are currently under extensive scrutiny. A …

Chromatin insulators are DNA–protein complexes that establish independent higher-order
DNA domains to influence transcription. Insulators are functionally defined by two properties …

Owing to the emerging applications of DNA-functionalized TiO 2 nanocrystals towards DNA
damage detection, it is inevitable to understand the better chemistry as well as in-depth …