Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but
also exert serious side effects. With in-depth studies of nucleotide metabolism, our …

When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy,
fixed doses were recommended by the manufacturer. Awareness of the potential for a more …

Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …

Nucleotides are essential to cell growth and survival, providing cells with building blocks for
DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the …

Nanoparticles have been found in large-scale environmental media in recent years, causing
toxic effects in various organisms and even humans through food chain transmission. The …

Abstract Di-(2-ethylhexyl) phthalate (DEHP) is one of the most extensively utilized
plasticizers in the plastic manufacturing process. It is widely used in various fields due to its …

Abnormal cancer metabolism occurs throughout the development of tumors. Recent studies
have shown that abnormal nucleotide metabolism not only accelerates the development of …

Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation
and an important factor for immune regulation. The purine de novo pathway and salvage …

Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine
nucleosides. PNP insufficiency in humans is paradoxically associated with both …