Acute myocardial infarction (MI) is a major cause of mortality and disability worldwide. In
patients with MI, the treatment option for reducing acute myocardial ischemic injury and …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Recent studies have implicated chemokines in microglial activation and pathogenesis of
neuropathic pain. CXC motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant …

Background Emerging evidence indicates that nerve damage–initiated neuroinflammation
and immune responses, which are evidenced by the up-regulation of proinflammatory …

Aging is a complex and progressive process that involves physiological and metabolic
deterioration in every organ and system. Cardiovascular diseases are one of the most …

A major shortcoming of postischemic therapy for myocardial infarction is the no‐reflow
phenomenon due to impaired cardiac microvascular function including microcirculatory …

Chronic pain is a notable health concern because of its prevalence, persistence, and
associated mental stress. Drugs targeting chronic pain with potent abirritation, and minimal …

Introduction Obesity's association with hand osteoarthritis cannot be fully explained by
mechanical loading. We examined the relationship between adipokines and radiographic …

Spinal cord astrocytes are critical in the maintenance of neuropathic pain. Connexin 43
(Cx43) expressed on spinal dorsal horn astrocytes modulates synaptic neurotransmission …

Obesity is associated with increased risk for chronic pain. Basic mechanisms for this
association are poorly understood. Using a milder version of a radicular pain model, local …