We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease
and a definite risk factor for many other diseases. Homocysteine is biosynthesized from …

Identification of modifiable risk factors provides a crucial approach to the prevention of
dementia. Nutritional or nutrient-dependent risk factors are especially important because …

Is it possible to prevent atrophy of key brain regions related to cognitive decline and
Alzheimer's disease (AD)? One approach is to modify nongenetic risk factors, for instance by …

Background An increased rate of brain atrophy is often observed in older subjects, in
particular those who suffer from cognitive decline. Homocysteine is a risk factor for brain …

Background In cross-sectional studies, elevated plasma homocysteine levels have been
associated with poor cognition and dementia. Studies of newly diagnosed dementia are …

Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …

▪ Abstract Homocysteine is a sulfur amino acid whose metabolism stands at the intersection
of two pathways: remethylation to methionine, which requires folate and vitamin B12 (or …

Background Homocysteine is a risk factor for Alzheimer's disease. In the first report on the
VITACOG trial, we showed that homocysteine‐lowering treatment with B vitamins slows the …

There are many reasons for reviewing the neurology of vitamin-B12 and folic-acid
deficiencies together, including the intimate relation between the metabolism of the two …