A great deal of experimental evidence suggests that ligands can stabilize different receptor
active states that go on to interact with cellular signaling proteins to form a range of different …

The primary goal of rational drug discovery is the identification of selective ligands which act
on single or multiple drug targets to achieve the desired clinical outcome through the …

Allosteric modulators bound to structurally diverse allosteric sites can achieve better
pharmacological advantages than orthosteric ligands. The discovery of allosteric …

G-protein-coupled receptors (GPCRs) have been tractable drug targets for decades with
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …

ABSTRACT Background Protein-protein interactions (PPIs) are intriguing targets for
designing novel small-molecule inhibitors. The role of PPIs in various infectious and …

The advent of advanced molecular modeling software, big data analytics, and high-speed
processing units has led to the exponential evolution of modern drug discovery and better …

Abstract G-protein-coupled receptor 12 (GPR12) is a brain-specific expression orphan G-
protein-coupled receptor (oGPCR) that regulates various physiological processes. It is an …

Schizophrenia is a severe brain disorder that usually produces a lifetime of disability. First
generation or typical antipsychotics such as haloperidol and second generation or atypical …

Modulators of the G protein-coupled A2A adenosine receptor (A2AAR) have been
considered promising agents to treat Parkinson's disease, inflammation, cancer, and central …

In this work, a new chromone based colorimetric sensor (ChrCS) was developed for highly
selective detection of copper ions in semi-aqueous media. Evaluation of color and spectral …