Cell death induced by endoplasmic reticulum stress
R Iurlaro, C Muñoz‐Pinedo - The FEBS journal, 2016 - Wiley Online Library
The endoplasmic reticulum is an organelle with multiple functions. The synthesis of
transmembrane proteins and proteins that are to be secreted occurs in this organelle. Many …
transmembrane proteins and proteins that are to be secreted occurs in this organelle. Many …
The role of cell signalling in the crosstalk between autophagy and apoptosis
LA Booth, S Tavallai, HA Hamed, N Cruickshanks… - Cellular signalling, 2014 - Elsevier
Not surprisingly, the death of a cell is a complex and well controlled process. For several
decades, apoptosis, the first genetically programmed death process to be identified has …
decades, apoptosis, the first genetically programmed death process to be identified has …
Autophagy mediates degradation of nuclear lamina
Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking
process that degrades a variety of cellular constituents and is associated with human …
process that degrades a variety of cellular constituents and is associated with human …
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway
Macroautophagy (autophagy) is a key catabolic pathway for the maintenance of proteostasis
through constant digestion of selective cargoes. The selectivity of autophagy is mediated by …
through constant digestion of selective cargoes. The selectivity of autophagy is mediated by …
Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates
Disruption of proteostasis, or protein homeostasis, is often associated with aberrant
accumulation of misfolded proteins or protein aggregates. Autophagy offers protection to …
accumulation of misfolded proteins or protein aggregates. Autophagy offers protection to …
Sphingolipids: regulators of crosstalk between apoptosis and autophagy
MM Young, M Kester, HG Wang - Journal of lipid research, 2013 - ASBMB
Apoptosis and autophagy are two evolutionarily conserved processes that maintain
homeostasis during stress. Although the two pathways utilize fundamentally distinct …
homeostasis during stress. Although the two pathways utilize fundamentally distinct …
TRIM21 ubiquitylates SQSTM1/p62 and suppresses protein sequestration to regulate redox homeostasis
TRIM21 is a RING finger domain-containing ubiquitin E3 ligase whose expression is
elevated in autoimmune disease. While TRIM21 plays an important role in immune …
elevated in autoimmune disease. While TRIM21 plays an important role in immune …
The LC3 interactome at a glance
Continuous synthesis of all cellular components requires their constant turnover in order for
a cell to achieve homeostasis. To this end, eukaryotic cells are endowed with two …
a cell to achieve homeostasis. To this end, eukaryotic cells are endowed with two …
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis
MM Young, Y Takahashi, O Khan, S Park, T Hori… - Journal of Biological …, 2012 - ASBMB
Autophagy and apoptosis are two evolutionarily conserved processes that regulate cell fate
in response to cytotoxic stress. However, the functional relationship between these two …
in response to cytotoxic stress. However, the functional relationship between these two …
Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy
HM Ni, BL Woolbright, J Williams, B Copple, W Cui… - Journal of …, 2014 - Elsevier
Background & Aims Autophagy is an intracellular lysosomal degradation process that plays
an important role in regulating normal physiological functions of the liver. The purpose of the …
an important role in regulating normal physiological functions of the liver. The purpose of the …