Background Lung cancer is a leading cause of cancer morbidity. To improve an
understanding of molecular causes of disease a transgenic mouse model was investigated …

Background Berberine (BBR), a component from traditional Chinese medicine, has been
shown to possess anti-tumor activity against a wide spectrum of cancer cells including …

Background p53 is the most frequently mutated tumor-suppressor gene in human cancers. It
has been reported that mutations in p53 result not only in the loss of its ability as a tumor …

Background The cellular apoptosis susceptibility (CAS) protein is regarded as a proliferation-
associated protein that associates with tumour proliferation as it associates with microtubule …

Purpose: Gallbladder cancers are cancers with high disease-specific mortality rates due to
the lack of early diagnosis and effective therapy. In this study, we evaluated whether CDC6 …

Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral cancer. Inducible
nitric oxide synthase (iNOS) and p53 are associated with a variety of human cancers, but …

Inducing apoptosis is an attractive antitumor strategy. PERP is an apoptosis-associated
target of p53, and its activation alone is sufficient to induce apoptotic pathway leading to cell …

Lung cancer is one of the cancers that have the highest incidence and the highest mortality
rate, and it is of great interest to identify ways to prevent its occurrence. We had established …

The role of bone morphogenetic proteins in the progression and metastasis of prostate
cancer is a topic that has undergone extensive research. This study investigates the role of …

Background: Keloids are fibroproliferative scars that develop as a result of a dysregulated
wound healing process; however, the molecular mechanisms of keloid pathogenesis remain …