The global epidemic of obesity is accompanied by an increased prevalence of
cardiovascular disease (CVD), in particular stroke and heart attack. Dysfunctional adipose …

Adiponectin is an important adipocyte‐derived hormone that regulates metabolism of lipids
and glucose, and its receptors (AdipoR1, AdipoR2, T‐cadherin) appear to exert actions in …

The endoplasmic reticulum (ER) is an essential cellular compartment in which an enormous
number of secretory and cell surface membrane proteins are synthesized and subjected to …

The knowledge of the pathogenesis of obesity and its metabolic sequelae has significantly
advanced over the last few decades and adipose tissue is now considered a link between …

Adiponectin is an insulin-sensitizing adipokine with protective effects against a cluster of
obesity-related metabolic and cardiovascular disorders. The adipokine exerts its insulin …

Rheumatoid arthritis (RA) is a systemic chronic inflammatory autoimmune joint disease,
characterized by progressive articular damage and joint dysfunction. One of the symptoms of …

Adiponectin (APN), which is an adipokine primarily secreted by adipose tissue into the
peripheral blood, exerts anti-inflammatory and metabolic regulatory functions in many …

Non-alcoholic fatty liver disease or steatosis is an accumulation of fat in the liver. Increased
amounts of non-esterified fatty acids, calcium deficiency, or insulin resistance may disturb …

The adipocytokine adiponectin and its receptor (AdipoR) comprise a new receptor-ligand
system that is involved in a variety of clinically important morbidities such as obesity, type 2 …

Adiponectin whose systemic levels are reduced in obesity-related diseases ameliorates
insulin sensitivity and regulates biological processes like apoptosis, proliferation, migration …