Breakthrough invasive fungal infections: Who is at risk?

JD Jenks, OA Cornely, SCA Chen, GR Thompson III… - Mycoses, 2020 - Wiley Online Library
The epidemiology of invasive fungal infections (IFIs) in immunocompromised individuals has
changed over the last few decades, partially due to the increased use of antifungal agents to …

Immunity to fungal infections

L Romani - Nature Reviews Immunology, 2011 - nature.com
Fungal diseases represent an important paradigm in immunology, as they can result from
either a lack of recognition by the immune system or overactivation of the inflammatory …

Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation

PY Bochud, JW Chien, KA Marr… - … England Journal of …, 2008 - Mass Medical Soc
Background Toll-like receptors (TLRs) are essential components of the immune response to
fungal pathogens. We examined the role of TLR polymorphisms in conferring a risk of …

Invasive aspergillosis: epidemiology, diagnosis and management in immunocompromised patients

G Maschmeyer, A Haas, OA Cornely - Drugs, 2007 - Springer
Morbidity and mortality caused by invasive Aspergillus infections are increasing. This is
because of the higher number of patients with malignancies treated with intensive …

Innate Immunity to Aspergillus Species

SJ Park, B Mehrad - Clinical microbiology reviews, 2009 - Am Soc Microbiol
All humans are continuously exposed to inhaled Aspergillus conidia, yet healthy hosts clear
the organism without developing disease and without the development of antibody-or cell …

Risk assessment and prognostic factors for mould-related diseases in immunocompromised patients

L Pagano, M Akova, G Dimopoulos… - Journal of …, 2011 - academic.oup.com
Invasive fungal diseases are important causes of morbidity and mortality in
immunocompromised patients. Patients with haematological malignancies and solid …

Epidemiology and treatment approaches in management of invasive fungal infections

J Kriengkauykiat, JI Ito, SS Dadwal - Clinical epidemiology, 2011 - Taylor & Francis
Over the past 20 years, the number of invasive fungal infections has continued to persist,
due primarily to the increased numbers of patients subjected to severe immunosuppression …

Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection

R Ben‐Ami, RE Lewis… - British journal of …, 2010 - Wiley Online Library
Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most
frequent cause of invasive fungal disease in immunosuppressed individuals. Recent …

[HTML][HTML] Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection

J Sainz, CB Lupiáñez, J Segura-Catena, L Vazquez… - PloS one, 2012 - journals.plos.org
The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity
mediated by the CCL2/CCR2 axis are critical steps in determining the host immune …

Risks, diagnosis and outcomes of invasive fungal infections in haematopoietic stem cell transplant recipients

PD Barnes, KA Marr - British journal of haematology, 2007 - Wiley Online Library
Invasive fungal infections (IFIs) continue to cause considerable morbidity and mortality in
haematopoietic stem cell transplant (HSCT) recipients. This review focuses on the risks for …