Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, has
a high mortality rate despite extensive efforts to develop new treatments. GBM exhibits both …

We designed a unique nanocapsule for efficient single CRISPR-Cas9 capsuling,
noninvasive brain delivery and tumor cell targeting, demonstrating an effective and safe …

Malignant tumors exhibit heterogeneous metabolic reprogramming, hindering the
identification of translatable vulnerabilities for metabolism-targeted therapy. How molecular …

Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent
technological advances, new insights into the molecular mechanisms underlying glioma …

Complete resection of isocitrate dehydrogenase 1 (IDH1)(R132H) glioma is unfeasible and
the classic post‐surgical chemo/radiotherapy suffers from high recurrence and low survival …

Heterotypic interactions across diverse cell types can enable tumor progression and hold
the potential to expand therapeutic interventions. Here, combined profiling and functional …

Cancer cells need a steady supply of nutrients to evade cell death and proliferate. Depriving
cancer cells of the amino acid cystine can trigger the non-apoptotic cell death process of …

The tumor-suppressive activity of p53 is largely attributed to its ability to induce cell death,
including apoptosis, through transcription-dependent and transcription-independent …

Abstract p53 is an important tumour suppressor gene, with loss of p53 contributing to the
development of most human cancers. However, the activation of p53 in response to stress …