▪ Abstract The heparan sulfate on the surface of all adherent cells modulates the actions of a
large number of extracellular ligands. Members of both cell surface heparan sulfate …

Glycosarninoglycans (GAGs) play an intricate role in the extracellular matrix (ECM), not only
as soluble components and polyelectrolytes, but also by specific interactions with growth …

During feeding by infected mosquitoes, malaria sporozoites are injected into the host's
bloodstream and enter hepatocytes within minutes. The remarkable target cell specificity of …

We describe cDNA clones for a cell surface proteoglycan that bears both heparan sulfate
and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. The cDNA …

Glycosylated forms of phosphatidylinositol, which have only recently been described in
eukaryotic organisms, are now known to play important roles in biological membrane …

Although proteoglycans constitute a minor component of vascular tissue, these molecules
have been shown to influence a number of arterial properties such as viscoelasticity …

A major prediction of the fluid mosaic model of membrane structure Ill was that proteins
would interact with the lipid bilayer only by non-covalent interactions. For most proteins (the …

Many proteins from a wide variety of eukaryotic cells owe their association with the external
face of the cell membrane to their covalently attached carboxy-terminal glycolipids. The …

Heparan sulfate proteoglycan, a componen; of endothelial cell membranes and extracellular
matrices, is involved in n number of the critical functions of endothelium and of antigen …

Neoplastic cells require an appropriate pericellular environment and new formation of
stroma and blood vessels in order to constitute a soilid tumor. Tumor progression also …