Computational modeling indicates that cardiac conduction may involve ephaptic coupling–
intercellular communication involving electrochemical signaling across narrow extracellular …

Cardiovascular disease remains the single largest cause of natural death in the United
States, with a significant cause of mortality associated with cardiac arrhythmias. Presently …

The intercalated disk (ID) is a specialized subcellular region that provides electrical and
mechanical connections between myocytes in the heart. The ID has a clearly defined …

It has been proposed that when gap junctional coupling is reduced in cardiac tissue, action
potential propagation can be supported via ephaptic coupling, a mechanism mediated by …

Electrical conduction in cardiac ventricular tissue is regulated via sodium (Na+) channels
and gap junctions (GJs). We and others have recently shown that Na+ channels …

The relationship between cardiac conduction velocity (CV) and extracellular potassium (K+)
is biphasic, with modest hyperkalemia increasing CV and severe hyperkalemia slowing CV …

Electrical conduction in cardiac tissue is usually considered to be primarily facilitated by gap
junctions, providing a pathway between the intracellular spaces of neighboring cells …

This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …

The standard conception of cardiac conduction is based on the cable theory of nerve
conduction, which treats cardiac tissue as a continuous syncytium described by the Hodgkin …

Connexin43‐formed gap junctions have long been thought to contribute to cardiac
conduction in the mammalian ventricle by providing direct electrotonic connectivity between …