Human protozoan diseases represent a serious health problem worldwide, affecting mainly
people in social and economic vulnerability. These diseases have attracted little investment …

Melatonin (MEL), an indoleamine hormone synthesized in almost all organisms including
humans, has been the object of a considerable body of research due to its pleiotropic …

Malaria elimination can benefit from time and cost-efficient approaches for antimalarials
such as drug repurposing. In this work, 796 DrugBank compounds were screened against …

A series of tailored novobiocin–ferrocene conjugates was prepared in moderate yields and
investigated for in vitro anticancer and antiplasmodial activity against the MDA-MB-231 …

This study involves the investigation of various plant parts of Breonadia salicina (Vahl)
Hepper and JRI Wood across multiple consecutive seasons. It aims to delve into the …

Purpose Major human parasitic protozoans, such as Plasmodium falciparum and
Trypanosoma brucei, cause malaria and trypanosomiasis also known as sleeping sickness …

Plasmodium, a digenetic parasite, requires a host and a vector for its life cycle completion.
Most Plasmodium species display circadian rhythmicity during their intraerythrocytic cycle …

The indoleamine compound melatonin has been extensively studied in the regulation of the
circadian rhythm in nearly all vertebrates. The effects of melatonin have also been studied in …

Melatonin and its indoles derivatives are central in the synchronization of malaria parasites.
In this research, we discovered that melatonin is unable to increase the parasitemia in the …

Quinoline-urea-benzothiazole hybrids exhibited low to sub-micromolar in vitro activities
against the Plasmodium falciparum (P. falciparum) 3D7 chloroquine (CQ)-sensitive strain …