Porcine Functional Spine Unit in orthopedic research, a systematic scoping review of the methodology
J Hedlund, L Ekström… - Journal of Experimental …, 2022 - Wiley Online Library
Purpose The aim of this study was to conduct a systematic scoping review of previous in
vitro spine studies that used pig functional spinal units (FSU) as a model to gain an …
vitro spine studies that used pig functional spinal units (FSU) as a model to gain an …
Mechanically induced histochemical and structural damage in the annulus fibrosus and cartilaginous endplate: a multi-colour immunofluorescence analysis
JD Zehr, FA Rahman, JP Callaghan… - Cell and Tissue …, 2022 - Springer
The annulus fibrosus (AF) and endplate (EP) are collagenous spine tissues that are
frequently injured due to gradual mechanical overload. Macroscopic injuries to these tissues …
frequently injured due to gradual mechanical overload. Macroscopic injuries to these tissues …
Incidence of Compression-Induced Microinjuries in the Cartilage Endplate of the Spine
Study Design. In vitro biomechanical study. Objective. This study investigated the incidence
of microstructural endplate injuries caused by cyclic compression loading. The covarying …
of microstructural endplate injuries caused by cyclic compression loading. The covarying …
Reaction Forces and Flexion–Extension Moments Imposed on Functional Spinal Units With Constrained and Unconstrained In Vitro Testing Systems
JD Zehr, JP Callaghan - Journal of …, 2022 - asmedigitalcollection.asme.org
A mechanical goal of in vitro testing systems is to minimize differences between applied and
actual forces and moments experienced by spinal units. This study quantified the joint …
actual forces and moments experienced by spinal units. This study quantified the joint …
Initiation and accumulation of loading induced changes to native collagen content and microstructural damage in the cartilaginous endplate
BACKGROUND CONTEXT Injury to the cartilaginous endplate (CEP) is linked to clinically
relevant low back disorders, including intervertebral disc degeneration and pain reporting …
relevant low back disorders, including intervertebral disc degeneration and pain reporting …
Cyclic loading history alters the joint compression tolerance and regional indentation responses in the cartilaginous endplate
This study quantified the effect of subthreshold loading histories that differed by joint posture
(neutral, flexed), peak loading variation (10%, 20%, 40%), and loading duration (1000 …
(neutral, flexed), peak loading variation (10%, 20%, 40%), and loading duration (1000 …
Experimentally dissociating the overuse mechanisms of endplate fracture lesions and Schmorl's node injuries using the porcine cervical spine model
JD Zehr, MI Watson, JP Callaghan - Clinical Biomechanics, 2023 - Elsevier
Background Compared to the documented overuse mechanisms of endplate fracture
lesions, the cause of Schmorl's node injuries remains unknown, despite existing …
lesions, the cause of Schmorl's node injuries remains unknown, despite existing …
The effect of failure mechanics on the fatigue responses of lumbar intervertebral disc
Q Liu, Q Zhang, CQ Zhang, AG Wang, ZC Xu… - Journal of …, 2024 - Elsevier
Lumbar disc herniation is usually caused by the accumulation of long-term mechanical
loads and sudden overload damage. Therefore, this study aims to illustrate how fatigue …
loads and sudden overload damage. Therefore, this study aims to illustrate how fatigue …
Towards the estimation of ultimate compression tolerance as a function of cyclic compression loading history: implications for lifting-related low back injury risk …
JD Zehr, JP Callaghan - Theoretical Issues in Ergonomics Science, 2023 - Taylor & Francis
This study aimed to mathematically characterize the ultimate compression tolerance (UCT)
as a function of spinal joint posture, loading variation, and loading duration. One hundred …
as a function of spinal joint posture, loading variation, and loading duration. One hundred …
A Biomechanical-Biochemical Hypothesis for the Role of Collagen in Injury
J Barrett - 2022 - uwspace.uwaterloo.ca
Low back pain affects 80% of the population at some point in their lives and is the most
common musculoskeletal complaint for workplace injuries. Further, it presents as episodic …
common musculoskeletal complaint for workplace injuries. Further, it presents as episodic …