Asciminib is a potent, orally bioavailable, investigational drug that specifically and potently
inhibits the tyrosine kinase activity of native ABL1, together with that of the chimeric BCR …

The structure-function paradigm has guided investigations into the molecules involved in
cellular signalling for decades. The peripheries of this paradigm, however, start to unravel …

Various lipids and lipid metabolites are bound to and modify the proteins in eukaryotic cells,
which are known as 'protein lipidation'. There are four major types of the protein lipidation, ie …

Highlights•Multivalent interactions of intrinsically disordered proteins (IDP) are highly
dynamic, leading to complex binding thermodynamics and kinetics and various functional …

Src is the representative member of the Src-family kinases (SFKs), a group of tyrosine
kinases involved in several cellular processes. Its main function has been for long confined …

Src plays a crucial role in many signaling pathways and contributes to a variety of cancers.
Therefore, Src has long been considered an attractive drug target in oncology. However, the …

Summary c-Src tyrosine kinase is a renowned key intracellular signaling molecule and a
potential target for cancer therapy. Secreted c-Src is a recent observation, but how it …

The assembly of complexes following the detection of extracellular signals is often controlled
by signaling proteins comprising multiple peptide binding modules. The SRC homology …

Simple Summary The human body relies on essential proteins for cellular growth and
development, which are synthesized according to the genetic code contained within the …

Src, a non-receptor tyrosine kinase, was first discovered as a prototype oncogene and has
been shown to critical for cancer progression for a variety of tissues. Src activity is regulated …