Sepsis, systemic hyper-inflammatory immune response, causes the increase of morbidity
and mortality rates due to multi-organ diseases such as neurotoxicity. Lipopolysaccharide …

There are nearly 50 million Alzheimer's disease (AD) patients worldwide, 90% of whom
develop behavioral and psychological symptoms of dementia (BPSD), which increase the …

Microglia are important in the development, homeostasis, and disorders of the central
nervous system. Neurodegenerative disorders such as Alzheimer's disease, Parkinson's …

Background Gastric ulcer is a very common gastrointestinal disease that may be dangerous
and even may lead to death. The current study was conducted to detect the prophylactic …

The aim of this study was to investigate the possible prophylactic effects of agomelatine
(AGO) against testicular and epididymal damage induced by methotrexate (MTX) in rats …

Agomelatine (AGOM) as an antidepressant acts both as a melatonin-receptor agonist and a
selective serotonin-receptor antagonist. As a potent melatonin derived antioxidant, AGOM …

Preclinical studies conducted so far suggest that oxidative stress processes may be
associated with the mechanism of depression development. This study shows the effects of …

Background Methotrexate (MTX), an anticancer drug, has been linked to multiple organ
toxicity. The drug-induced acute toxic symptoms can negatively affect the patient's …

Side effects of doxorubicin (DOX) are mainly due to oxidative stress, with the involvement of
inflammatory and apoptotic mechanisms. Agomelatine (AGO) is a melatonin receptor …

Major depressive disorder (MDD) is one of the foremost causes of disability and premature
death worldwide. Although the available antidepressants are effective and well tolerated …