An unprecedented revolution in medicinal chemistry driven by the progress of biological science

KC Chou - Current topics in medicinal chemistry, 2017 - ingentaconnect.com
The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …

Pseudo nucleotide composition or PseKNC: an effective formulation for analyzing genomic sequences

W Chen, H Lin, KC Chou - Molecular BioSystems, 2015 - pubs.rsc.org
With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent
to develop automated methods for analyzing the relationship between the sequences and …

[HTML][HTML] Pse-in-One 2.0: an improved package of web servers for generating various modes of pseudo components of DNA, RNA, and protein sequences

B Liu, H Wu, KC Chou - Natural science, 2017 - scirp.org
Pse-in-One 2.0 is a package of web-servers evolved from Pse-in-One (Liu, B., Liu, F., Wang,
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …

An effective image representation method using kernel classification

H Wang, J Wang - 2014 IEEE 26th international conference on …, 2014 - ieeexplore.ieee.org
The learning of image representation is always the most important problem in computer
vision community. In this paper, we propose a novel image representation method by …

PseAAC-Builder: A cross-platform stand-alone program for generating various special Chou's pseudo-amino acid compositions

P Du, X Wang, C Xu, Y Gao - Analytical biochemistry, 2012 - Elsevier
The pseudo-amino acid composition has been widely used to convert complicated protein
sequences with various lengths to fixed length digital feature vectors while keeping …

A treatise to computational approaches towards prediction of membrane protein and its subtypes

AH Butt, N Rasool, YD Khan - The Journal of membrane biology, 2017 - Springer
Membrane proteins are vital mediating molecules responsible for the interaction of a cell
with its surroundings. These proteins are involved in different functionalities such as ferrying …

A two-stage SVM method to predict membrane protein types by incorporating amino acid classifications and physicochemical properties into a general form of Chou's …

GS Han, ZG Yu, V Anh - Journal of Theoretical Biology, 2014 - Elsevier
Membrane proteins play important roles in many biochemical processes and are also
attractive targets of drug discovery for various diseases. The elucidation of membrane …

Predicting membrane protein types by incorporating a novel feature set into Chou's general PseAAC

ES Sankari, D Manimegalai - Journal of Theoretical Biology, 2018 - Elsevier
Membrane proteins are vital type of proteins that serve as channels, receptors and energy
transducers in a cell. They perform various important functions, which are mainly associated …

Identification of adaptor proteins using the ANOVA feature selection technique

YH Wang, YF Zhang, Y Zhang, ZF Gu, ZY Zhang, H Lin… - Methods, 2022 - Elsevier
The adaptor proteins play a crucially important role in regulating lymphocyte activation.
Rapid and efficient identification of adaptor proteins is essential for understanding their …

Identification of mycobacterial membrane proteins and their types using over-represented tripeptide compositions

C Ding, LF Yuan, SH Guo, H Lin, W Chen - Journal of proteomics, 2012 - Elsevier
Mycobacterium can cause many serious diseases, such as tuberculosis and leprosy. Its
membrane proteins play a critical role for multidrug-resistance and its tenacious survival …