Detergents are widely used for membrane protein solubilization, purification, and structural
analysis. Over the past two decades, much effort has been made to design novel detergents …

Background Membrane proteins constitute a major group of proteins and are of great
significance as pharmaceutical targets, but underrepresented in the Protein Data Bank …

Membrane proteins play essential roles in a number of biological processes, and their
structures are important in elucidating such processes at the molecular level and also for …

Membrane proteins are of biological and pharmaceutical significance. However, their
structural study is extremely challenging mainly due to the fact that only a small number of …

Limited by the rare efficient extraction system in extracting hydrophobic membrane protein
complexes (MPCs) without compromising the stability of protein–protein interactions (PPIs) …

Membrane protein structures provide atomic level insight into essential biochemical
processes and facilitate protein structure-based drug design. However, the inherent …

Maintaining protein stability in an aqueous solution is a prerequisite for protein structural
and functional studies, but conventional detergents have increasingly showed limited ability …

To tackle the problems associated with membrane protein (MP) instability in detergent
solutions, we designed a series of glycosyl‐substituted dicarboxylate detergents (DCODs) in …

Amphiphilic agents, called detergents, are invaluable tools for studying membrane proteins.
However, membrane proteins encapsulated by conventional head-to-tail detergents tend to …

Alkyl glycosides as modern industrial manufactured products are important. Furthermore, the
better water solubility should make them a greater potential application value. In this study …