Platelet granules are unique among secretory vesicles in both their content and their life
cycle. Platelets contain three major granule types—dense granules, α-granules, and …

Unique functions of specialised cells such as those of the immune and haemostasis
systems, skin, blood vessels, lung, and bone require specialised compartments, collectively …

Cancer cells secrete copious amounts of exosomes, and elevated intracellular Ca2+ is
critical for tumor progression and metastasis, but the underlying cellular mechanisms are …

Platelet granules contribute to many aspects of host defense, including hemostasis and
thrombosis, inflammation, angiogenesis, and wound healing. These granules store high …

Secretion is essential to many of the roles that platelets play in the vasculature, eg,
thrombosis, angiogenesis, and inflammation, enabling platelets to modulate the …

Although granule secretion is pivotal in many platelet responses, the fusion routes of α and δ
granule release remain uncertain. We used a 3D reconstruction approach based on electron …

Anaphylaxis is a notorious type 2 immune response which may result in a systemic
response and lead to death. A precondition for the unfolding of the anaphylactic shock is the …

Background Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory disorder
characterized by a life-threatening cytokine storm and immunopathology. Familial HLH type …

Objective—Platelet secretion is crucial for many physiological platelet responses. Even
though several regulators of the fusion machinery for secretory granule exocytosis have …

Platelet degranulation is crucial for hemostasis and may participate in inflammation.
Exocytosis in platelets is mediated by SNARE proteins and should be controlled by Munc13 …