Plasmodium vivax Latent Liver Stage Infection and Relapse: Biological Insights and New Experimental Tools
Plasmodium vivax is the most widespread human malaria parasite, in part because it can
form latent liver stages known as hypnozoites after transmission by female anopheline …
form latent liver stages known as hypnozoites after transmission by female anopheline …
Are physiological oscillations physiological?
L Xiong, A Garfinkel - The Journal of Physiology, 2023 - Wiley Online Library
Despite widespread and striking examples of physiological oscillations, their functional role
is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen …
is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen …
Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum
Plasmodium falciparum secretes extracellular vesicles (Pf EVs) that contain parasite-derived
RNA. However, the significance of the secreted RNA remains unexplored. Here, we …
RNA. However, the significance of the secreted RNA remains unexplored. Here, we …
The malaria parasite has an intrinsic clock
Malarial rhythmic fevers are the consequence of the synchronous bursting of red blood cells
(RBCs) on completion of the malaria parasite asexual cell cycle. Here, we hypothesized that …
(RBCs) on completion of the malaria parasite asexual cell cycle. Here, we hypothesized that …
Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics
How do cells perceive time? Do cells use temporal information to regulate the production/
degradation of their enzymes, membranes, and organelles? Does controlling biological time …
degradation of their enzymes, membranes, and organelles? Does controlling biological time …
Laser-induced surface acoustic wave sensing-based malaria parasite detection and analysis
Malaria parasite-Plasmodium falciparum infection is a severe healthcare problem in tropical
and subtropical regions. Early detection of such disease is vital in reducing mortality and …
and subtropical regions. Early detection of such disease is vital in reducing mortality and …
A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin
Dynamic control of gene expression is critical for blood stage development of malaria
parasites. Here, we used multi-omic analyses to investigate transcriptional regulation by the …
parasites. Here, we used multi-omic analyses to investigate transcriptional regulation by the …
A comprehensive rhythmicity analysis of host proteins and immune factors involved in malaria pathogenesis to decipher the importance of host circadian clock in …
Background Circadian rhythms broadly impact human health by regulating our daily
physiological and metabolic processes. The circadian clocks substantially regulate our …
physiological and metabolic processes. The circadian clocks substantially regulate our …
How many is enough?-Challenges of multinucleated cell division in malaria parasites
CS Simon, VS Stürmer, J Guizetti - Frontiers in cellular and infection …, 2021 - frontiersin.org
Regulating the number of progeny generated by replicative cell cycles is critical for any
organism to best adapt to its environment. Classically, the decision whether to divide further …
organism to best adapt to its environment. Classically, the decision whether to divide further …
Daily rhythms in gene expression of the human parasite Schistosoma mansoni
Background The consequences of the earth's daily rotation have led to 24-h biological
rhythms in most organisms. Even some parasites are known to have daily rhythms, which …
rhythms in most organisms. Even some parasites are known to have daily rhythms, which …