Dysregulation of peptide-activated pathways causes a range of diseases, fostering the
discovery and clinical development of peptide drugs. Many endogenous peptides activate G …

Chronic kidney disease (CKD) is a leading cause of global morbidity and mortality and is
independently associated with cardiovascular disease. The mainstay of treatment for CKD is …

The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has emerged to a
pandemic and caused global public health crisis. Human angiotensin-converting enzyme 2 …

The angiotensin II (AngII) type 1 receptor (AT1R) is a critical regulator of cardiovascular and
renal function and is an important model for studies of G-protein-coupled receptor (GPCR) …

GPR52 is a class-A orphan G-protein-coupled receptor that is highly expressed in the brain
and represents a promising therapeutic target for the treatment of Huntington's disease and …

Short ORFs (sORFs), that is, occurrences of a start and stop codon within 100 codons or
less, can be found in organisms of all domains of life, outnumbering annotated protein …

G protein-coupled receptors (GPCRs) are critical regulators of human physiology and make
up the largest single class of therapeutic drug targets. Although GPCRs regulate highly …

The technique of cryogenic-electron microscopy (cryo-EM) has revolutionized the field of
membrane protein structure and function with a focus on the dominantly observed molecular …

Apelin and Elabela (ELA) are endogenous ligands of angiotensin domain type 1 receptor-
associated proteins (APJ). Apelin/ELA-APJ signal is widely distributed in the cardiovascular …

Frizzled receptors (FZDs) are class-F G-protein-coupled receptors (GPCRs) that function in
Wnt signalling and are essential for developing and adult organisms,. As central mediators …