Macrolides have diverse biological activities and an ability to modulate inflammation and
immunity in eukaryotes without affecting homeostatic immunity. These properties have led to …

Airway epithelial cells play a major role in initiating inflammation in response to bacterial
pathogens. S. aureus is an important pathogen associated with activation of diverse types of …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

Staphylococcus aureus is a major human pathogen that is associated with diverse types of
local and systemic infection characterized by inflammation dominated by …

Macrolide antibiotics administered in sub-antimicrobial doses improve pulmonary function
and decrease exacerbation frequency for persons with diffuse panbronchiolitis or cystic …

Every day, we breathe in more than 10,000 L of air that contains a variety of air pollutants
that can pose negative consequences to lung health. The respiratory mucosa formed by the …

Human cytomegalovirus virus (CMV) is a major cause of morbidity and mortality in
immunocompromised individuals. Recently, a novel group of cytokines [interleukin (IL) …

Macrolide antibiotics decrease proinflammatory cytokine production in airway cells from
subjects with chronic airway inflammation. However, in subjects with chronic obstructive …

We investigated and compared the mechanisms by which two dust mite proteolytic
allergens, Der p 1 and Der p 3, and a peptide agonist of proteinase-activated receptor 2 …

Cystic fibrosis (CF) is characterized by prolonged and excessive inflammatory responses in
the lung and increased activation of NF-κB. Parthenolide is a sesquiterpene lactone derived …