Pluripotent stem cells can be derived from embryos or induced from adult cells by
reprogramming. They are unique among stem cells in that they can give rise to all cell types …

The vertebrate lung consists of multiple cell types that are derived primarily from endodermal
and mesodermal compartments of the early embryo. The process of pulmonary …

Abstract Pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-
like helicase (RLH) receptors, are involved in innate immune antiviral responses. Here we …

Yeast Rpd3 histone deacetylase plays an important role at actively transcribed genes. We
characterized two distinct Rpd3 complexes, Rpd3L and Rpd3S, by MudPIT analysis. Both …

The deoxyribonucleic acid (DNA) damage response (DDR) is a major feature in the
maintenance of genome integrity and in the suppression of tumorigenesis. PALB2 (Partner …

The functional organization of eukaryotic genomes correlates with specific patterns of
histone methylations. Regulatory regions in genomes such as enhancers and promoters …

Human MRG15 is a transcription factor that plays a vital role in embryonic development, cell
proliferation and cellular senescence. It comprises a putative chromo domain in the N …

Mammalian cells have developed complex mechanisms to identify DNA damage and
activate the required response to maintain genome integrity. Those mechanisms include …

Splicing can be epigenetically regulated and involved in cellular differentiation in somatic
cells, but the interplay of epigenetic factors and the splicing machinery during …

MRG15 is a conserved chromodomain protein that associates with histone deacetylases
(HDACs) and Tip60‐containing histone acetyltransferase (HAT) complexes. Here we further …