Mitochondrial DNA maintenance in vertebrates
GS Shadel, DA Clayton - Annual review of biochemistry, 1997 - annualreviews.org
The discovery that mutations in mitochondrial DNA (mtDNA) can be pathogenic in humans
has increased interest in understanding mtDNA maintenance. The functional state of mtDNA …
has increased interest in understanding mtDNA maintenance. The functional state of mtDNA …
Function and synthesis of small nucleolar RNAs
D Tollervey, T Kiss - Current opinion in cell biology, 1997 - Elsevier
Eukaryotic cells contain an extraordinary complex population of small nucleolar RNAs
(snoRNAs). During its brief lifetime, each human pre-rRNA molecule will transiently …
(snoRNAs). During its brief lifetime, each human pre-rRNA molecule will transiently …
[HTML][HTML] The kink‐turn: a new RNA secondary structure motif
Analysis of the Haloarcula marismortui large ribosomal subunit has revealed a common
RNA structure that we call the kink‐turn, or K‐turn. The six K‐turns in H. marismortui 23S …
RNA structure that we call the kink‐turn, or K‐turn. The six K‐turns in H. marismortui 23S …
[HTML][HTML] Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia
M Ridanpää, H Van Eenennaam, K Pelin, R Chadwick… - Cell, 2001 - cell.com
The recessively inherited developmental disorder, cartilage-hair hypoplasia (CHH) is highly
pleiotropic with manifestations including short stature, defective cellular immunity, and …
pleiotropic with manifestations including short stature, defective cellular immunity, and …
The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functions
AG Balakin, L Smith, MJ Fournier - cell, 1996 - cell.com
We have discovered that all known yeast and vertebrate small nucleolar RNAs (snoRNAs),
except for the MRP/7–2 RNA, fall into two major classes. One class is defined by conserved …
except for the MRP/7–2 RNA, fall into two major classes. One class is defined by conserved …
Transcription and replication of mitochondrial DNA
DA Clayton - Human reproduction, 2000 - academic.oup.com
The physical isolation of mammalian mitochondrial DNA (mtDNA) over 30 years ago marked
the beginning of studies of its structure, replication and the expression of its genetic content …
the beginning of studies of its structure, replication and the expression of its genetic content …
The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA …
P Ganot, M Caizergues-Ferrer, T Kiss - Genes & development, 1997 - genesdev.cshlp.org
Eukaryotic cells contain a large number of small nucleolar RNAs (snoRNAs). A major family
of snoRNAs features a consensus ACA motif positioned 3 nucleotides from the 3'end of the …
of snoRNAs features a consensus ACA motif positioned 3 nucleotides from the 3'end of the …
snoRNPs: functions in ribosome biogenesis
Ribosomes are perhaps the most critical macromolecular machine as they are tasked with
carrying out protein synthesis in cells. They are incredibly complex structures composed of …
carrying out protein synthesis in cells. They are incredibly complex structures composed of …
Detection of RNA–protein interactions in living cells with SHAPE
SHAPE-MaP is unique among RNA structure probing strategies in that it both measures
flexibility at single-nucleotide resolution and quantifies the uncertainties in these …
flexibility at single-nucleotide resolution and quantifies the uncertainties in these …
Nuclear RNase MRP is Required for Correct Processing of pre-5.8S rRNA in Saccharomyces cerevisiae
ME Schmitt, DA Clayton - Molecular and cellular biology, 1993 - Taylor & Francis
RNase MRP is a site-specific ribonucleoprotein endoribonuclease that cleaves RNA from
the mitochondrial origin of replication in a manner consistent with a role in priming leading …
the mitochondrial origin of replication in a manner consistent with a role in priming leading …