[HTML][HTML] High intensity focused ultrasound in clinical tumor ablation

YF Zhou - World journal of clinical oncology, 2011 - ncbi.nlm.nih.gov
Recent advances in high intensity focused ultrasound (HIFU), which was developed in the
1940s as a viable thermal tissue ablation approach, have increased its popularity. In clinics …

[HTML][HTML] For whom the bubble grows: physical principles of bubble nucleation and dynamics in histotripsy ultrasound therapy

KB Bader, E Vlaisavljevich, AD Maxwell - Ultrasound in medicine & biology, 2019 - Elsevier
Histotripsy is a focused ultrasound therapy for non-invasive tissue ablation. Unlike thermally
ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of …

Histotripsy: a method for mechanical tissue ablation with ultrasound

Z Xu, TD Khokhlova, CS Cho… - Annual Review of …, 2024 - annualreviews.org
Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy
tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to …

Shock-induced heating and millisecond boiling in gels and tissue due to high intensity focused ultrasound

MS Canney, VA Khokhlova, OV Bessonova… - Ultrasound in medicine …, 2010 - Elsevier
Nonlinear propagation causes high-intensity ultrasound waves to distort and generate
higher harmonics, which are more readily absorbed and converted to heat than the …

Controlled tissue emulsification produced by high intensity focused ultrasound shock waves and millisecond boiling

TD Khokhlova, MS Canney, VA Khokhlova… - The Journal of the …, 2011 - pubs.aip.org
In high intensity focused ultrasound (HIFU) applications, tissue may be thermally necrosed
by heating, emulsified by cavitation, or, as was recently discovered, emulsified using …

Methods of monitoring thermal ablation of soft tissue tumors–A comprehensive review

R Geoghegan, G Ter Haar, K Nightingale… - Medical …, 2022 - Wiley Online Library
Thermal ablation is a form of hyperthermia in which oncologic control can be achieved by
briefly inducing elevated temperatures, typically in the range 50–80° C, within a target …

MR‐guided focused ultrasound surgery, present and future

D Schlesinger, S Benedict, C Diederich… - Medical …, 2013 - Wiley Online Library
MR‐guided focused ultrasound surgery (MRgFUS) is a quickly developing technology with
potential applications across a spectrum of indications traditionally within the domain of …

Histological and biochemical analysis of mechanical and thermal bioeffects in boiling histotripsy lesions induced by high intensity focused ultrasound

YN Wang, T Khokhlova, M Bailey, JH Hwang… - Ultrasound in medicine …, 2013 - Elsevier
Recent studies have shown that shockwave heating and millisecond boiling in high-intensity
focused ultrasound fields can result in mechanical fractionation or emulsification of tissue …

Combined passive detection and ultrafast active imaging of cavitation events induced by short pulses of high-intensity ultrasound

J Gateau, JF Aubry, M Pernot, M Fink… - IEEE transactions on …, 2011 - ieeexplore.ieee.org
The activation of natural gas nuclei to induce larger bubbles is possible using short
ultrasonic excitations of high amplitude, and is required for ultrasound cavitation therapies …

A study of bubble activity generated in ex vivo tissue by high intensity focused ultrasound

J McLaughlan, I Rivens, T Leighton… - Ultrasound in medicine & …, 2010 - Elsevier
Cancer treatment by extracorporeal high-intensity focused ultrasound (HIFU) is constrained
by the time required to ablate clinically relevant tumour volumes. Although cavitation may be …