[HTML][HTML] Drug treatments in Alzheimer's disease

R Briggs, SP Kennelly, D O'Neill - Clinical medicine, 2016 - Elsevier
Despite the significant public health issue that it poses, only five medical treatments have
been approved for Alzheimer's disease (AD) and these act to control symptoms rather than …

Current and future treatments in Alzheimer's disease

A Atri - Seminars in neurology, 2019 - thieme-connect.com
The foundation of current Alzheimer's disease (AD) treatment involves pharmacological and
nonpharmacological management and care planning predicated on patient-centered …

[HTML][HTML] X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women

Y Yan, X Wang, D Chaput, MK Shin, Y Koh, L Gan… - Cell, 2022 - cell.com
Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Therapeutics of Alzheimer's disease: Past, present and future

R Anand, KD Gill, AA Mahdi - Neuropharmacology, 2014 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …

The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain

A Gasiorowska, M Wydrych, P Drapich… - Frontiers in aging …, 2021 - frontiersin.org
The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

Therapeutics of neurotransmitters in Alzheimer's disease

R Kandimalla, PH Reddy - Journal of Alzheimer's Disease, 2017 - content.iospress.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by the
loss of memory, multiple cognitive impairments and changes in the personality and …

Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease

N Kumar, V Kumar, P Anand, V Kumar… - Bioorganic & Medicinal …, 2022 - Elsevier
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

The Alzheimer's disease clinical spectrum: diagnosis and management

A Atri - Medical Clinics, 2019 - medical.theclinics.com
Alzheimer's disease (AD) is the most common cause of cognitive impairment or dementia in
individuals older than 65 years and, with rising longevity, a worldwide pandemic of mild …

Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease

CG Parsons, W Danysz, A Dekundy, I Pulte - Neurotoxicity research, 2013 - Springer
This review describes the preclinical mechanisms that may underlie the increased
therapeutic benefit of combination therapy—with the N-methyl-d-aspartate receptor …

Pharmacotherapy evolution in Alzheimer's disease: current framework and relevant directions

DC Miculas, PA Negru, SG Bungau, T Behl, SS Hassan… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD), once considered a rare disease, is now the most common form of
dementia in the elderly population. Current drugs (cholinesterase inhibitors and glutamate …