The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

Implantable biosensors are valuable scientific tools for basic neuroscience research and
clinical applications. Neurotechnologies provide direct readouts of neurological signal and …

Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic
use for over 30 years because of its antibiotic properties against both gram‐positive and …

The distinguishing pathogenic features of neurodegenerative diseases include
mitochondrial dysfunction and derived reactive oxygen species generation. The neural …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Minocycline is commonly used to inhibit microglial activation. It is widely accepted that
activated microglia exert dual functions, that is, pro-inflammatory (M1) and anti-inflammatory …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a non-
cell autonomous motor neuron loss. While it is generally believed that the disease onset …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease affecting upper and
lower motor neurons in the central nervous system. Patients with ALS develop extensive …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis (ALS) are characterised by the appearance of reactive …

Oxidative stress has long been linked to the neuronal cell death that is associated with
certain neurodegenerative conditions. Whether it is a primary cause or merely a downstream …