Comet assay: an essential tool in toxicological research

M Glei, T Schneider, W Schlörmann - Archives of toxicology, 2016 - Springer
The comet assay is a versatile, reliable, cost-efficient, and fast technique for detecting DNA
damage and repair in any tissue. It is useable in almost any cell type and applicable to both …

3-MCPD as contaminant in processed foods: State of knowledge and remaining challenges

A Eisenreich, BH Monien, ME Götz, T Buhrke… - Food Chemistry, 2023 - Elsevier
Chloro-1, 2-propanediol (3-MCPD) and its fatty acid esters (FE) are present as contaminants
in different processed foods. Based on the available toxicological data the potential risk of 3 …

Gut homeostasis and microbiota under attack: Impact of the different types of food contaminants on gut health

MM Elmassry, A Zayed, MA Farag - Critical Reviews in Food …, 2022 - Taylor & Francis
Food contaminants represent food constituents that are accidentally introduced during food
preparation cycle. In addition to their direct toxic effects on human health at different levels …

Exposure assessment of process-related contaminants in food by biomarker monitoring

IMCM Rietjens, P Dussort, H Günther, P Hanlon… - Archives of …, 2018 - Springer
Exposure assessment is a fundamental part of the risk assessment paradigm, but can often
present a number of challenges and uncertainties. This is especially the case for process …

Toxicity of Dietary Exposure to 3‐Monochloropropanediol, Glycidol, and Their Fatty Acid Esters

DS Yabani, IW Ofosu, GM Ankar-Brewoo… - Journal of Food …, 2024 - Wiley Online Library
3‐Monochloropropane‐1, 2‐diol (3‐MCPD), 2, 3‐epoxy‐1‐propanol (glycidol), and their
fatty acid esters are heat‐induced food toxicants that have widely been investigated. This …

Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform

JE Seo, X He, L Muskhelishvili, P Malhi, N Mei… - Altex, 2022 - osti.gov
Three-dimensional (3D) culture systems are increasingly being used for genotoxicity studies
due to improved cell-to-cell interactions and tissue-like structures that are limited or lacking …

In vitro toxicological assessment of free 3-MCPD and select 3-MCPD esters on human proximal tubule HK-2 cells

ME Mossoba, MST Mapa, M Araujo, Y Zhao… - Cell Biology and …, 2020 - Springer
Chloropropanols are chemical contaminants that can be formed during industrial processing
of foods, such as lipids used in commercially available infant and toddler formula in the USA …

[HTML][HTML] Assessment of intestinal absorption/metabolism of 3-chloro-1, 2-propanediol (3-MCPD) and three 3-MCPD monoesters by Caco-2 cells

M Araujo, JK Beekman, MST Mapa, S MacMahon… - Toxicology in vitro, 2020 - Elsevier
chloro-1, 2-propanediol (3-MCPD) and 3-MCPD esters are contaminants present in a variety
of processed foods, including infant formulas. Toxicological data are unavailable in humans …

[PDF][PDF] 同位素内标-气相色谱-质谱法测定婴幼儿配方乳粉中缩水甘油脂肪酸酯的含量

胡守江, 周静, 张妮, 周耀斌, 赵艳菊, 叶青 - 理化检验-化学分册, 2018 - qikan.cmes.org
将奶粉样品(4.000 0 g) 的氨性乙醇溶液用乙醚(25, 15, 15 mL) 和石油醚(25, 15, 15 mL) 先后3
次提取其脂肪; 合并上层液相, 蒸发除去溶剂后于(100±2)℃ 烘干, 于4℃ 保存 …

DNA Damage Estimation after Chronic and Combined Exposure to Endocrine Disruptors: An In Vivo Real-Life Risk Simulation Approach

V Karzi, E Ozcagli, MN Tzatzarakis, E Vakonaki… - International Journal of …, 2023 - mdpi.com
Exposure to chemical substances has always been a matter of concern for the scientific
community. During the last few years, researchers have been focusing on studying the …