Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

Human mucosal-associated invariant T (MAIT) cells are a T cell population characterized by
the expression of a semi-invariant TCR capable of recognizing bacterial products in the …

▪ Abstract Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique
properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an …

CD1d-restricted natural killer (NK) T cells are known to potently secrete T helper (Th) 1 and
Th2 cytokines and to mediate cytolysis, but it is unclear how these contrasting functional …

CD8+ T lymphocytes play a key role in host defense, in particular against important
persistent viruses, although the critical functional properties of such cells in tissue are not …

CD1d-restricted autoreactive natural killer (NK) T cells have been reported to regulate a
range of disease conditions, including type I diabetes and immune rejection of cancer …

Modification in the function of dendritic cells (DC), such as that achieved by microbial stimuli
or T cell help, plays a critical role in determining the quality and size of adaptive responses …

Unlike their protein “roommates” and their nucleic acid “cousins," carbohydrates remain an
enigmatic arm of biology. The central reason for the difficulty in fully understanding how …

Neutrophils are the main effector cells during inflammation, but they can also control
excessive inflammatory responses by secreting anti-inflammatory cytokines. However, the …