Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …

Every cell in nature carries a rich surface coat of glycans, its glycocalyx, which constitutes
the cell's interface with its environment. In eukaryotes, the glycocalyx is composed of …

The immune system of the infant is functionally immature and naïve. Human milk contains
bioactive proteins, lipids, and carbohydrates that protect the newborn and stimulate innate …

Sialic acid sugars on the surface of cancer cells have emerged as potent immune
modulators that contribute to the immunosuppressive microenvironment and tumor immune …

Sialylated N-glycans play essential roles in the immune system, pathogen recognition and
cancer. This review approaches the sialylation of N-glycans from three perspectives. The …

Sialic acids are a family of negatively charged monosaccharides which are commonly
presented as the terminal residues in glycans of the glycoconjugates on eukaryotic cell …

Gangliosides are sialic acid‐containing glycosphingolipids. They occur especially on the
cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in …

This chapter describes the variable components of N-glycans, O-glycans, and glycolipids
attached to the core of each glycan class and presented in Chapters 9, 10, and 11. The …

Abstract 'Salt & Pepper'syndrome is an autosomal recessive condition characterized by
severe intellectual disability, epilepsy, scoliosis, choreoathetosis, dysmorphic facial features …

As an anti-adhesive, a reservoir for key biological molecules, and a modulator of signaling,
polysialic acid (polySia) is critical for nervous system development and maintenance …