Targeting macrophages in cancer immunotherapy
Z Duan, Y Luo - Signal transduction and targeted therapy, 2021 - nature.com
Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
Mechanisms of bone development and repair
A Salhotra, HN Shah, B Levi… - Nature reviews Molecular …, 2020 - nature.com
Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …
formation of the body scaffold. The repair potential of bone and its surrounding …
Osteoclast differentiation by RANKL and OPG signaling pathways
N Udagawa, M Koide, M Nakamura… - Journal of bone and …, 2021 - Springer
Introduction In bone tissue, bone resorption by osteoclasts and bone formation by
osteoblasts are repeated continuously. Osteoclasts are multinucleated cells that derive from …
osteoblasts are repeated continuously. Osteoclasts are multinucleated cells that derive from …
Osteoimmunology: evolving concepts in bone–immune interactions in health and disease
M Tsukasaki, H Takayanagi - Nature Reviews Immunology, 2019 - nature.com
In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …
Osteoblast-osteoclast communication and bone homeostasis
Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and
bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to …
bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to …
The osteocyte: new insights
AG Robling, LF Bonewald - Annual review of physiology, 2020 - annualreviews.org
Osteocytes are an ancient cell, appearing in fossilized skeletal remains of early fish and
dinosaurs. Despite its relative high abundance, even in the context of nonskeletal cells, the …
dinosaurs. Despite its relative high abundance, even in the context of nonskeletal cells, the …
Developmental origin, functional maintenance and genetic rescue of osteoclasts
Osteoclasts are multinucleated giant cells that resorb bone, ensuring development and
continuous remodelling of the skeleton and the bone marrow haematopoietic niche …
continuous remodelling of the skeleton and the bone marrow haematopoietic niche …
The bone remodelling cycle
JS Kenkre, JHD Bassett - Annals of clinical biochemistry, 2018 - journals.sagepub.com
The bone remodelling cycle replaces old and damaged bone and is a highly regulated,
lifelong process essential for preserving bone integrity and maintaining mineral …
lifelong process essential for preserving bone integrity and maintaining mineral …
Coupling of bone resorption and formation by RANKL reverse signalling
Y Ikebuchi, S Aoki, M Honma, M Hayashi, Y Sugamori… - Nature, 2018 - nature.com
Receptor activator of nuclear factor-kappa B (RANK) ligand (RANKL) binds RANK on the
surface of osteoclast precursors to trigger osteoclastogenesis. Recent studies have …
surface of osteoclast precursors to trigger osteoclastogenesis. Recent studies have …