Circuit mechanisms of Parkinson's disease

MM McGregor, AB Nelson - Neuron, 2019 - cell.com
Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The
second most common neurodegenerative disorder after Alzheimer's disease, it affects …

Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?

J Blesa, G Foffani, B Dehay, E Bezard… - Nature Reviews …, 2022 - nature.com
For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …

Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Molecular and anatomical organization of the dorsal raphe nucleus

KW Huang, NE Ochandarena, AC Philson, M Hyun… - Elife, 2019 - elifesciences.org
The dorsal raphe nucleus (DRN) is an important source of neuromodulators and has been
implicated in a wide variety of behavioral and neurological disorders. The DRN is …

Fatigue in Parkinson's disease: a systematic review and meta‐analysis

M Siciliano, L Trojano, G Santangelo… - Movement …, 2018 - Wiley Online Library
We conducted a systematic review and meta‐analysis aimed at establishing robust
prevalence estimates and identifying clinical correlates of fatigue in PD. From 2,459 titles …

Comprehensive mapping of neurotransmitter networks by MALDI–MS imaging

M Shariatgorji, A Nilsson, E Fridjonsdottir… - Nature …, 2019 - nature.com
We present a mass spectrometry imaging (MSI) approach for the comprehensive mapping of
neurotransmitter networks in specific brain regions. Our fluoromethylpyridinium-based …

Functions of p38 MAP kinases in the central nervous system

PR Asih, E Prikas, K Stefanoska, ARP Tan… - Frontiers in molecular …, 2020 - frontiersin.org
Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …

Compensatory mechanisms in Parkinson's disease: circuits adaptations and role in disease modification

J Blesa, I Trigo-Damas, M Dileone, NLG Del Rey… - Experimental …, 2017 - Elsevier
The motor features of Parkinson's disease (PD) are well known to manifest only when striatal
dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-motor …

Probiotics alleviate the progressive deterioration of motor functions in a mouse model of Parkinson's disease

TH Hsieh, CW Kuo, KH Hsieh, MJ Shieh, CW Peng… - Brain sciences, 2020 - mdpi.com
Parkinson's disease (PD) is one of the common long-term degenerative disorders that
primarily affect motor systems. Gastrointestinal (GI) symptoms are common in individuals …

The role of neuroimaging in Parkinson's disease

NSR Bidesi, I Vang Andersen… - Journal of …, 2021 - Wiley Online Library
Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people
worldwide. Two hallmarks of PD are the accumulation of alpha‐synuclein and the loss of …