SUMMARY A major part of organismal complexity and versatility of prokaryotes resides in
their ability to fine-tune gene expression to adequately respond to internal and external …

Microorganisms in most ecological niches are constantly exposed to variations of many
environmental factors, including temperature; oxygen, nutrient, and water availability; …

The structure of complex transcriptional regulatory networks has been studied extensively in
certain model organisms. However, the evolutionary dynamics of these networks across …

With the availability of genome sequences for hundreds of microbial genomes, it has
become possible to address several questions from a comparative perspective to …

Background Bacterial genome sequences are being determined rapidly, but few species are
physiologically well characterized. Predicting regulation from genome sequences usually …

Abstract The National Center for Biotechnology Information (NCBI) recently announced
'1000 prokaryotic genomes are now completed and available in the Genome database'. The …

Understanding the mechanisms by which transcriptional regulatory networks (TRNs) change
through evolution is a fundamental problem. Here, we analyze this question using data from …

Background Transcriptional regulation of gene activity is essential for any living organism.
Transcription factors therefore recognize specific binding sites within the DNA to regulate the …

Abstract The version 2.0 of Tractor_DB is now accessible at its three international mirrors:,
and. This database contains a collection of computationally predicted Transcription Factors' …

ABSTRACT The AsnC/Lrp family of regulatory proteins links bacterial and archaeal
transcription patterns to metabolism. In Escherichia coli, Lrp regulates approximately 400 …