α-Synuclein is a protein with a molecular weight of 14.5 kDa and consists of 140 amino
acids encoded by the SNCA gene. Missense mutations and gene duplications in the SNCA …

Parkinson's disease (PD) is the most common neurological movement disorder
characterized by the selective and irreversible loss of dopaminergic neurons in substantia …

Background Parkinson's disease (PD) is a prevalent neurological disease in the elderly with
increasing morbidity and mortality. Despite enormous efforts, rapid and accurate diagnosis …

Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

We have previously shown that a fatty acid-binding protein7 (FABP7) inhibitor ameliorates
cerebral ischemia-reperfusion injury in mice, suggesting an association between FABPs and …

Nigrostriatal dopaminergic systems govern physiological functions related to locomotion,
and their dysfunction leads to movement disorders, such as Parkinson's disease and dopa …

α-synuclein accumulation into dopaminergic neurons is a pathological hallmark of
Parkinson's disease. We previously demonstrated that fatty acid-binding protein 3 (FABP3) …

Abstract α-Synuclein (α-Syn) is closely related to the pathogenesis of Parkinson's disease
(PD). Under pathological conditions, the conformation of α-syn changes and different forms …

Endocytosis is the fundamental uptake process through which cells internalize extracellular
materials and species. Neurodegenerative diseases (NDs) are characterized by a …

Oligomerization and/or aggregation of α-synuclein (α-Syn) triggers α-synucleinopathies
such as Parkinson's disease and dementia with Lewy bodies. It is known that α-Syn can …