1. INTRODUCTION Indoline-2, 3-dione or indole-1H-2, 3-dione (Figure 1), commonly known
as isatin, is a well-known natural product found in plants of genus Isatis and in Couropita …

Tuberculosis (TB) is one of the most common and even fatal infectious diseases known to
mankind. Millions of new cases are reported every year over the world, and one-third of the …

Nowadays, it's imperative to develop novel antimicrobial agents active against both drug-
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …

One of the interesting research fields is developing and assessing novel metal-containing
medications. A new isatin-3-thiosemicarbazone derivative 4 was synthesized by two …

Isatin has been widely used in drug discovery. The ring is part of many naturally occurring
compounds and is used to design compounds with diverse biological activities. These isatin …

In recent decades, several viruses have resulted in large outbreaks with serious health,
economic and social consequences. The current unprecedented outbreak of the new …

Abstract Reaction of 5-(morpholinisulfonyl) isatin (1) with thiosemicarbazide derivative
appended the corresponding thiosemicarbazone derivative 3 that further coordinated with …

Hybridization of different pharmacophores from various bioactive substances into a single
molecule is the potential weapon to prevent the drug resistance since this strategy can …

As a continuation of our previous efforts on N-alkyl/aryl-N′-[4-(4-alkyl/aryl-2, 4-dihydro-3H-
1, 2, 4-triazole-3-thione-5-yl) phenyl] thioureas 1–19 and N-alkyl/aryl-N′-[4-(3-aralkylthio-4 …

Thiosemicarbazones (TSCs) are a class of Schiff bases usually obtained by the
condensation of thiosemicarbazide with a suitable aldehyde or ketone. TSCs have been the …