[HTML][HTML] Biocatalysis
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …
academia and across the chemical and pharmaceutical industries. Its success has been …
Power of biocatalysis for organic synthesis
CK Winkler, JH Schrittwieser, W Kroutil - ACS central science, 2021 - ACS Publications
Biocatalysis, using defined enzymes for organic transformations, has become a common
tool in organic synthesis, which is also frequently applied in industry. The generally high …
tool in organic synthesis, which is also frequently applied in industry. The generally high …
Drivers and impacts of the most extreme marine heatwave events
Prolonged high-temperature extreme events in the ocean, marine heatwaves, can have
severe and long-lasting impacts on marine ecosystems, fisheries and associated services …
severe and long-lasting impacts on marine ecosystems, fisheries and associated services …
Loop dynamics and the evolution of enzyme activity
In the early 2000s, Tawfik presented his 'New View'on enzyme evolution, highlighting the
role of conformational plasticity in expanding the functional diversity of limited repertoires of …
role of conformational plasticity in expanding the functional diversity of limited repertoires of …
Biofunctionalized 3D printed structures for biomedical applications: A critical review of recent advances and future prospects
One of the greatest trends currently revolutionizing healthcare is the introduction of
advanced additive manufacturing techniques, also known as 3D printing, for personalized …
advanced additive manufacturing techniques, also known as 3D printing, for personalized …
Intrinsic enzymatic properties modulate the self-propulsion of micromotors
Bio-catalytic micro-and nanomotors self-propel by the enzymatic conversion of substrates
into products. Despite the advances in the field, the fundamental aspects underlying enzyme …
into products. Despite the advances in the field, the fundamental aspects underlying enzyme …
The challenge of predicting distal active site mutations in computational enzyme design
S Osuna - Wiley Interdisciplinary Reviews: Computational …, 2021 - Wiley Online Library
Many computational enzyme design approaches have been developed in recent years that
focus on a reduced set of key enzymatic features. Initial protocols mostly focused on the …
focus on a reduced set of key enzymatic features. Initial protocols mostly focused on the …
How directed evolution reshapes the energy landscape in an enzyme to boost catalysis
The advent of biocatalysts designed computationally and optimized by laboratory evolution
provides an opportunity to explore molecular strategies for augmenting catalytic function …
provides an opportunity to explore molecular strategies for augmenting catalytic function …
Decrypting Allostery in Membrane-Bound K-Ras4B Using Complementary In Silico Approaches Based on Unbiased Molecular Dynamics Simulations
M Castelli, F Marchetti, S Osuna… - Journal of the …, 2023 - ACS Publications
Protein functions are dynamically regulated by allostery, which enables conformational
communication even between faraway residues, and expresses itself in many forms, akin to …
communication even between faraway residues, and expresses itself in many forms, akin to …
Evolution of dynamical networks enhances catalysis in a designer enzyme
Activation heat capacity is emerging as a crucial factor in enzyme thermoadaptation, as
shown by the non-Arrhenius behaviour of many natural enzymes. However, its physical …
shown by the non-Arrhenius behaviour of many natural enzymes. However, its physical …