[HTML][HTML] Biocatalysis

EL Bell, W Finnigan, SP France, AP Green… - Nature Reviews …, 2021 - nature.com
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Power of biocatalysis for organic synthesis

CK Winkler, JH Schrittwieser, W Kroutil - ACS central science, 2021 - ACS Publications
Biocatalysis, using defined enzymes for organic transformations, has become a common
tool in organic synthesis, which is also frequently applied in industry. The generally high …

Drivers and impacts of the most extreme marine heatwave events

A Sen Gupta, M Thomsen, JA Benthuysen… - Scientific reports, 2020 - nature.com
Prolonged high-temperature extreme events in the ocean, marine heatwaves, can have
severe and long-lasting impacts on marine ecosystems, fisheries and associated services …

Loop dynamics and the evolution of enzyme activity

M Corbella, GP Pinto, SCL Kamerlin - Nature Reviews Chemistry, 2023 - nature.com
In the early 2000s, Tawfik presented his 'New View'on enzyme evolution, highlighting the
role of conformational plasticity in expanding the functional diversity of limited repertoires of …

Biofunctionalized 3D printed structures for biomedical applications: A critical review of recent advances and future prospects

O Lotz, DR McKenzie, MM Bilek, B Akhavan - Progress in Materials …, 2023 - Elsevier
One of the greatest trends currently revolutionizing healthcare is the introduction of
advanced additive manufacturing techniques, also known as 3D printing, for personalized …

Intrinsic enzymatic properties modulate the self-propulsion of micromotors

X Arqué, A Romero-Rivera, F Feixas, T Patiño… - Nature …, 2019 - nature.com
Bio-catalytic micro-and nanomotors self-propel by the enzymatic conversion of substrates
into products. Despite the advances in the field, the fundamental aspects underlying enzyme …

The challenge of predicting distal active site mutations in computational enzyme design

S Osuna - Wiley Interdisciplinary Reviews: Computational …, 2021 - Wiley Online Library
Many computational enzyme design approaches have been developed in recent years that
focus on a reduced set of key enzymatic features. Initial protocols mostly focused on the …

How directed evolution reshapes the energy landscape in an enzyme to boost catalysis

R Otten, RAP Pádua, HA Bunzel, V Nguyen… - Science, 2020 - science.org
The advent of biocatalysts designed computationally and optimized by laboratory evolution
provides an opportunity to explore molecular strategies for augmenting catalytic function …

Decrypting Allostery in Membrane-Bound K-Ras4B Using Complementary In Silico Approaches Based on Unbiased Molecular Dynamics Simulations

M Castelli, F Marchetti, S Osuna… - Journal of the …, 2023 - ACS Publications
Protein functions are dynamically regulated by allostery, which enables conformational
communication even between faraway residues, and expresses itself in many forms, akin to …

Evolution of dynamical networks enhances catalysis in a designer enzyme

HA Bunzel, JLR Anderson, D Hilvert, VL Arcus… - Nature Chemistry, 2021 - nature.com
Activation heat capacity is emerging as a crucial factor in enzyme thermoadaptation, as
shown by the non-Arrhenius behaviour of many natural enzymes. However, its physical …