Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell
death. Although these cell death programmes can protect the host against microbial …

Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …

Ferroptosis is a nonapoptotic, iron-dependent form of cell death that can be activated in
cancer cells by natural stimuli and synthetic agents. Three essential hallmarks define …

Cell death plays an important role during pathogen infections. Here, we report that interferon-
γ (IFNγ) sensitizes macrophages to Toll-like receptor (TLR)-induced death that requires …

Caspases are an evolutionary conserved family of cysteine-dependent proteases that are
involved in many vital cellular processes including apoptosis, proliferation, differentiation …

Background & Aims Non-alcoholic steatohepatitis (NASH) is characterized by hepatocyte
steatosis, ballooning, and lobular inflammation which may lead to fibrosis. Lipotoxicity …

Non-Alcoholic Steatohepatitis (NASH) is the progressive form of Non-Alcoholic Fatty Liver
Disease (NAFLD), the main cause of chronic liver complications. The development of NASH …

Unleashing the immune system with immune checkpoint inhibitors (ICI) has significantly
improved overall survival for subsets of patients with stage III/IV cancer. However, many …