Structure and dynamics of nanoconfined water and aqueous solutions
HR Corti, GA Appignanesi, MC Barbosa… - The European Physical …, 2021 - Springer
This review is devoted to discussing recent progress on the structure, thermodynamic,
reactivity, and dynamics of water and aqueous systems confined within different types of …
reactivity, and dynamics of water and aqueous systems confined within different types of …
Physics of the nuclear pore complex: Theory, modeling and experiment
The hallmark of eukaryotic cells is the nucleus that contains the genome, enclosed by a
physical barrier known as the nuclear envelope (NE). On the one hand, this …
physical barrier known as the nuclear envelope (NE). On the one hand, this …
Tau protein disrupts nucleocytoplasmic transport in Alzheimer's disease
B Eftekharzadeh, JG Daigle, LE Kapinos, A Coyne… - Neuron, 2018 - cell.com
Tau is the major constituent of neurofibrillary tangles in Alzheimer's disease (AD), but the
mechanism underlying tau-associated neural damage remains unclear. Here, we show that …
mechanism underlying tau-associated neural damage remains unclear. Here, we show that …
Spatiotemporal dynamics of the nuclear pore complex transport barrier resolved by high-speed atomic force microscopy
Y Sakiyama, A Mazur, LE Kapinos, RYH Lim - Nature nanotechnology, 2016 - nature.com
Nuclear pore complexes (NPCs) are biological nanomachines that mediate the bidirectional
traffic of macromolecules between the cytoplasm and nucleus in eukaryotic cells. This …
traffic of macromolecules between the cytoplasm and nucleus in eukaryotic cells. This …
IDPs in macromolecular complexes: the roles of multivalent interactions in diverse assemblies
Highlights•Intrinsically disordered proteins have diverse roles in macromolecular
complexes.•Short sequences, repeated within disordered regions give rise to multivalent …
complexes.•Short sequences, repeated within disordered regions give rise to multivalent …
Simulation methods for liquid–liquid phase separation of disordered proteins
Liquid–liquid phase separation of intrinsically disordered proteins (IDPs) and other
biomolecules is a highly complex but robust process used by living systems. Drawing …
biomolecules is a highly complex but robust process used by living systems. Drawing …
[HTML][HTML] Phase separation of FG-nucleoporins in nuclear pore complexes
The nuclear envelope (NE) is a bilayer membrane that separates and physically isolates the
genetic material from the cytoplasm. Nuclear pore complexes (NPCs) are cylindrical …
genetic material from the cytoplasm. Nuclear pore complexes (NPCs) are cylindrical …
Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations
Highlights•Low complexity (LC) sequences are prominent in eukaryotic proteomes.•LC
sequences are composed of a parsimonious subset of the naturally occurring amino …
sequences are composed of a parsimonious subset of the naturally occurring amino …
Coacervation of poly-electrolytes in the presence of lipid bilayers: mutual alteration of structure and morphology
Many intrinsically disordered peptides have been shown to undergo liquid–liquid phase
separation and form complex coacervates, which play various regulatory roles in the cell …
separation and form complex coacervates, which play various regulatory roles in the cell …
Function of the nuclear transport machinery in maintaining the distinctive compositions of the nucleus and cytoplasm
M Stewart - International journal of molecular sciences, 2022 - mdpi.com
Although the separation of transcription and translation, mediated by the nuclear envelope,
is the defining characteristic of Eukaryotes, the barrier between the nuclear and cytoplasmic …
is the defining characteristic of Eukaryotes, the barrier between the nuclear and cytoplasmic …