Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

Sáez, Juan C., Viviana M. Berthoud, María C. Brañes, Agustín D. Martínez, and Eric C.
Beyer. Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions …

Connexins (Cxs) form hemichannels and gap junction channels. Each gap junction channel
is composed of two hemichannels, also termed connexons, one from each of the coupled …

Plasma membrane hemichannels composed of connexin (Cx) proteins are essential
components of gap junction channels but accumulating evidence suggests functions of …

Connexin hemichannels (connexons) are building blocks of gap junctions but also function
as free unapposed channels, which has become an active field of research. Defining …

Vertebrate cells that express connexins likely express connexin hemichannels (Cx HCs) at
their surface. In diverse cell types, surface Cx HCs can open to serve as a diffusional …

Gap junctions formed by connexins (Cx) play an important role in transmitting signals
between bone cells such as osteoblasts and osteoclasts, cells responsible for bone …

Connexins are protein subunits that oligomerize into hexamers called connexons, gap
junction hemichannels or just hemichannels. Because some gap junction channels are …

The normal function and survival of cells in the avascular lens is facilitated by intercellular
communication through an extensive network of gap junctions formed predominantly by …

Lens fiber connexins, cx50 and cx46 (α3 and α8), belong to a small subset of connexins that
can form functional hemichannels in nonjunctional membranes. Knockout of either cx50 or …