Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

Alzheimer's disease (AD) represents the main form of dementia, and is a major public health
problem. Despite intensive research efforts, current treatments have only marginal …

Translocase of outer mitochondrial membrane 40 (TOMM40) is located in the outer
membrane of mitochondria. TOMM40 is essential for protein import into mitochondria …

Multiscale integration of gene transcriptomic and neuroimaging data is becoming a widely
used approach for exploring the molecular underpinnings of large‐scale brain organization …

Sirtuins (SIRT1-7) are NAD+-dependent protein deacetylases/ADP ribosyltransferases with
important roles in chromatin silencing, cell cycle regulation, cellular differentiation, cellular …

Introduction Variants in the tau gene (MAPT) region are associated with breast cancer in
women and Alzheimer's disease (AD) among persons lacking apolipoprotein E ε4 (ε4–) …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by
abnormal protein accumulation, synaptic dysfunction, and cognitive impairment. The …

Despite advances, the roles of genetic variants from the APOE-harboring 19q13. 32 region
in Alzheimer's disease (AD) remain controversial. We leverage a comprehensive approach …

The Apolipoprotein E (APOE) locus has garnered significant clinical interest because of its
association with Alzheimer's disease (AD) and longevity. This genetic association appears …

Mitochondrial dysfunction is an important factor in the pathogenesis of age-related diseases,
including neurodegenerative diseases like Alzheimer's and Parkinson's spectrum disorders …