Natural killer cells in cancer biology and therapy

SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …

Uterine fibroids and infertility

D Freytag, V Günther, N Maass, I Alkatout - Diagnostics, 2021 - mdpi.com
Infertility is a disease of the reproductive system defined by the failure to achieve a clinical
pregnancy after 12 months or more of regular unprotected sexual intercourse. Uterine …

KIR receptors as key regulators of NK cells activity in health and disease

J Dębska-Zielkowska, G Moszkowska, M Zieliński… - Cells, 2021 - mdpi.com
Natural killer (NK) cells are part of the cellular immune response. They target mainly cancer
and virally infected cells. To a high extent cytotoxic activity of NK cells is regulated inter alia …

HLA-G: An important mediator of maternal-fetal immune-tolerance

B Zhuang, J Shang, Y Yao - Frontiers in Immunology, 2021 - frontiersin.org
Maternal-fetal immune-tolerance occurs throughout the whole gestational trimester, thus a
mother can accept a genetically distinct fetus without immunological aggressive behavior …

Crosstalk between trophoblasts and decidual immune cells: the cornerstone of maternal-fetal immunotolerance

L Xu, Y Li, Y Sang, DJ Li, M Du - Frontiers in immunology, 2021 - frontiersin.org
The success of pregnancy relies on the fine adjustment of the maternal immune system to
tolerate the allogeneic fetus. Trophoblasts carrying paternal antigens are the only fetal …

Uterine natural killer cells: A rising star in human pregnancy regulation

M Xie, Y Li, YZ Meng, P Xu, YG Yang, S Dong… - Frontiers in …, 2022 - frontiersin.org
Uterine natural killer (uNK) cells are an immune subset located in the uterus. uNK cells have
distinct tissue-specific characteristics compared to their counterparts in peripheral blood and …

[HTML][HTML] Human leukocyte antigens: the unique expression in trophoblasts and their crosstalk with local immune cells

XX Lin, YM Xie, SJ Zhao, CY Liu, G Mor… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Trophoblasts differentiate and form the placenta during pregnancy in a complex and finely
orchestrated process, which is dependent on the establishment of maternal-fetal immune …

Human leukocyte immunoglobulin-like receptors in health and disease

S Redondo-García, C Barritt, C Papagregoriou… - Frontiers in …, 2023 - frontiersin.org
Human leukocyte immunoglobulin (Ig)-like receptors (LILR) are a family of 11 innate
immunomodulatory receptors, primarily expressed on lymphoid and myeloid cells. LILRs are …

[HTML][HTML] PD-1 is expressed by and regulates human group 3 innate lymphoid cells in human decidua

P Vacca, S Pesce, M Greppi, E Fulcheri, E Munari… - Mucosal …, 2019 - Elsevier
Group 3 innate lymphoid cells (ILC3) have been detected in both murine and human
decidual tissues where they are thought to play a relevant role in the induction and …

Identification of molecular subtypes and immune infiltration in endometriosis: a novel bioinformatics analysis and In vitro validation

S Lv, J Sun, L Gan, J Sun - Frontiers in Immunology, 2023 - frontiersin.org
Introduction Endometriosis is a worldwide gynacological diseases, affecting in 6–10% of
women of reproductive age. The aim of this study was to investigate the gene network and …