Molecular imaging of apoptosis: the case of caspase-3 radiotracers
L Beroske, T Van den Wyngaert, S Stroobants… - International journal of …, 2021 - mdpi.com
The molecular imaging of apoptosis remains an important method for the diagnosis and
monitoring of the progression of certain diseases and the evaluation of the efficacy of …
monitoring of the progression of certain diseases and the evaluation of the efficacy of …
Sulfur (VI) fluoride exchange (SuFEx)-enabled high-throughput medicinal chemistry
Optimization of small-molecule probes or drugs is a synthetically lengthy, challenging, and
resource-intensive process. Lack of automation and reliance on skilled medicinal chemists …
resource-intensive process. Lack of automation and reliance on skilled medicinal chemists …
Covalent small molecule immunomodulators targeting the protease active site
HR Kim, R Tagirasa, E Yoo - Journal of Medicinal Chemistry, 2021 - ACS Publications
Cells of the immune system utilize multiple proteases to regulate cell functions and
orchestrate innate and adaptive immune responses. Dysregulated protease activities are …
orchestrate innate and adaptive immune responses. Dysregulated protease activities are …
In vivo, in vitro and in silico anticancer investigation of fullerene C60 on DMBA induced breast cancer in rats
Aims The aim of the study was to determine the protective and therapeutic effect of fullerene
C 60 nanoparticle on DMBA-induced breast cancer in rats. Main methods In vitro cell …
C 60 nanoparticle on DMBA-induced breast cancer in rats. Main methods In vitro cell …
Synthesis, characterization, molecular docking, and anticancer activities of new 1, 3, 4-oxadiazole-5-fluorocytosine hybrid derivatives
Abstract Analogs of pyrimidine and 1, 3, 4-oxadiazole are two well established class of
molecules proven as potent antiviral and anticancer agents in the pharmaceutical industry …
molecules proven as potent antiviral and anticancer agents in the pharmaceutical industry …
Mitochondrial permeability transition causes mitochondrial reactive oxygen species-and caspase 3-dependent atrophy of single adult mouse skeletal muscle fibers
Elevated mitochondrial reactive oxygen species (mROS) and an increase in caspase-3
activity are established mechanisms that lead to skeletal muscle atrophy via the …
activity are established mechanisms that lead to skeletal muscle atrophy via the …
Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular …
Ellagic acid (EA) has protective effect on testicular damage and this natural compound
decreases oxidative damage. The present study aims to examine the preventive effect of …
decreases oxidative damage. The present study aims to examine the preventive effect of …
Development of fluorescent dual-FRET probe for simultaneous detection of caspase-8 and caspase-9 activities and their relative quantification
M Porubský, E Řezníčková, S Křupková, V Kryštof… - Bioorganic …, 2022 - Elsevier
A multi-FRET three-fluorophore probe containing coumarin, fluorescein and rhodamine B
with two enzymatically cleavable linkers has been synthesized and optimized for the …
with two enzymatically cleavable linkers has been synthesized and optimized for the …
Biogenic Synthesized Bare and Boron-Doped Copper Oxide Nanoparticles from Thymbra spicat ssp. spicata: In Silico and In Vitro Studies
The biosynthesis technique and biogenic copper oxide nanoparticles (CuONPs) are
commonly used in a variety of applications including medicine. Bare (CuONPs) and boron …
commonly used in a variety of applications including medicine. Bare (CuONPs) and boron …
Signal execution modes emerge in biochemical reaction networks calibrated to experimental data
Mathematical models of biomolecular networks are commonly used to study cellular
processes; however, their usefulness to explain and predict dynamic behaviors is often …
processes; however, their usefulness to explain and predict dynamic behaviors is often …